Time Table and Program (PDF 50KB)
- Wednesday, July 14
- Thursday, July 15
- Session 1. Molecular mechanisms of TGF-β family signaling
- Session 2. TGF-β signaling and cancer
- Friday, July 16
- Session 3. TGF-β signaling and vascular, bone, and other diseases
- Saturday, July 17
- Session 4. Implications in TGF-β-based therapies
- Poster Session A
- Poster Session B
Wednesday, July 14
| 14:00 - 21:00 | Check-in / Registration / Poster Hanging |
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| 19:00 - 21:00 | Poster Viewing / Welcome Reception in Foyer (2nd floor) |
Thursday, July 15
| 9:00 - 9:30 | Opening Remarks Introductory Video Presentation of Fujihara Seminar Greeting Soji Ban (The Fujihara Foundation of Science) Introductory Remarks Kohei Miyazono (University of Tokyo) |
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Session 1. Molecular mechanisms of TGF-β family signaling
Chair: Carl-Henrik Heldin (Uppsala University)
| 9:30 - 10:00 | Carl-Henrik Heldin (Uppsala University) Non-Smad signaling downstream of TGF-β receptors |
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| 10:00 - 10:30 | Mitsuyasu Kato (University of Tsukuba) Smad traps for negative regulation of TGF-β signaling |
| 10:30 - 11:00 | Poster Viewing / Coffee Break |
| 11:00 - 11:30 | Aristidis Moustakas (Uppsala University) Negative regulation of TGFβ and Smad signaling |
| 11:30 - 12:00 | Keiji Miyazawa (Yamanashi University) An Id-like molecule, Maid, is a cellular-response selective regulator of TGF-β signaling |
| 12:00 - 12:30 | Xin-Hua Feng (Baylor College of Medicine) Coupled Actions of PPM1A and RanBP3 Terminate SMAD Nuclear Functions |
| 12:30 - 14:00 | Lunch |
| 14:00 - 14:30 | Rosemary Akhurst (UCSF) Genes that regulate the phenotypic outcome of altered TGF-β signaling in vivo: A mouse-to-human genetics approach |
Session 2. TGF-β signaling and cancer
Chair: Xiao-Fan Wang (Duke University)
| 14:30 - 15:00 | Xiao-Fan Wang (Duke University) TGF-β promotes hepatocellular carcinoma intrahepatic metastasis by enhancing Treg cell recruitment via miR-34a-CCL22 pathway |
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| 15:00 - 15:30 | Kunxin Luo (UC Berkeley) Expression and function of SnoN in normal mammary gland development |
| 15:30 - 16:00 | Poster Viewing / Coffee Break |
| 16:00 - 16:30 | Takeshi Imamura (Cancer Institute of JFCR) Nuclear Receptors Inhibit TGF-β Signaling Pathway via Smad Degradation: Implication for Cancer Progression |
| 16:30 - 17:00 | Xiao-Jing Wang (University of Colorado Denver) Distinct roles of Smads in squamous cell carcinomas |
| 17:00 - 18:00 | Poster Session A |
| 19:00 - 21:00 | Banquet at Grandview (16th Floor) |
Friday, July 16
| 7:30 - 8:30 | Business meeting of JSPS Core-to-Core Program |
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Session 3. TGF-β signaling and vascular, bone, and other diseases
Chair: Rik Derynck (UCSF)
| 9:00 - 9:30 | Rik Derynck (UCSF) Role of mTOR signaling in TGF-β-induced EMT |
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| 9:30 - 10:00 | Hideyuki Beppu (University of Toyama) BMPR2-deficiency causes abnormal cell proliferation in cardiovascular and intestinal tracts |
| 10:00 - 10:30 | Ye-Guang Chen (Tsinghua University) Genome-wide Analysis of Smad Targets Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination |
| 10:30 - 11:00 | Poster Viewing / Coffee Break |
| 11:00 - 11:30 | Akiko Hata (Tufts Medical Center) Regulation of Vascular Smooth Muscle Cell Phenotype by TGF-β |
| 11:30 - 12:00 | Peter ten Dijke (Leiden University) TGF-β signaling in tumor cell invasion and angiogenesis |
| 12:00 - 13:30 | Group Photo / Lunch |
| 13:30 - | Excursion / Free time |
| 17:00 - 18:00 | Poster Session B |
| 19:00 - 21:00 | Dinner |
Saturday, July 17
Session 4. Implications in TGF-β-based therapies
Chair: Seong-Jin Kim (Gachon University of Medicine and Science)
| 9:00 - 9:30 | Seong-Jin Kim (Gachon University of Medicine and Science) Association of TRAF6 and the type III TGF-β receptor bridges IL-1b-mediated repression of TGF-β signaling |
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| 9:30 - 10:00 | S. Paul Oh (University of Florida) Roles of TGF-β receptors in vascular development and diseases |
| 10:00 - 10:30 | Makoto Mark Taketo (Kyoto University) Inactivation of TGF-β signaling and colon cancer liver metastasis: Role of CCR1+ immature myeloid cells |
| 10:30 - 11:00 | Poster Viewing / Coffee Break |
| 11:00 - 11:30 | Atsushi Hirao (Kanazawa University) Roles of TGF-β/FoxO in the maintenance of leukemia stem cells |
| 11:30 - 12:00 | HQ Han (Amgen) Pharmacological Blockade of Myostatin and Activin Leads to Reversal of Cancer Cachexia and Prolongation of Lifespan in Tumor-Bearing Animals |
| 12:00 - 12:15 | Closing Remarks Susumu Nishimura (The Fujihara Foundation of Science) Kohei Miyazono (University of Tokyo) |
| 12:30 - | Lunch / Departure |
Poster Session A (Thursday, July 15)
| A01 | Eunjin Bae (Gachon University of Medicine and Science) Traf6 is a key mediator of TGF-β induced metastasis |
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| A02 | Kana Horiguchi (University of Tokyo) Molecular mechanism of Snail induction by TGF-β |
| A03 | Yukari Hoshino (University of Tokyo) Autocrine TGF-β protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim |
| A04 | Ja-shil Hyun (Gachon University of Medicine and Science) Smad7 enhances the proteasomal degradation of c-Myc protein by binding FBW7 |
| A05 | Kimihito C. Kawabata (University of Tokyo) TGF-β downregulates CD20 and inhibits growth of B lymphoma cells. |
| A06 | Young-Woong Kim (Gachon University of Medicine and Science) N-linked glycosylation is essential for the stability and cell surface localization of type II TGF-β receptor |
| A07 | Hyun-Joo Lee (Gachon University of Medicine and Science) Divergent Roles of Smad2 and Smad3 in the Regulation of Arthritogenic T Helper 17 Cells |
| A08 | Hajime Mihira (University of Tokyo) TGF-β2 induces endothelial-mesenchymal transition of MS-1 endothelial cells |
| A09 | Koji Miyabayashi (University of Tokyo) Preclinical Molecular Targeting Therapy of Pancreatic Cancer using a Genetically Engineered Mouse Model |
| A10 | Naoko Nakano (University of Tsukuba) TCF7L2 coordinates with Smads to regulate TGF-β-mediated transcription of TMEPAI gene |
| A11 | Yo-taro Shirai (University of Tokyo) BMP plays a tumor suppressive role in diffuse-type gastric carcinoma development |
| A12 | Kyung-Min Yang (Gachon University of Medicine and Science) DRAK2 binds to the TGF-β receptors to suppress TGF-β signaling pathway. |
| A13 | Jeong-Hwan Yoon (Gachon University of Medicine and Science) TGF-β signaling through Smad3 and Smad4 targets Eomesodermin to suppress CD8+ cytotoxic T cells in DNFB-induced contact hypersensitivity |
| A14 | Kwiyeom Yoon (Gachon University of Medicine and Science) Expression analysis of TGF-β signaling-related genes and identification of novel SNPs by total RNA sequencing in human gastric cancer cell lines |
Poster Session B (Friday, July 16)
| B01 | Shogo Ehata (University of Tokyo) TGF-β diminishes the SP fraction of the diffuse-type gastric carcinoma cells |
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| B02 | Hideaki Ijichi (University of Tokyo) Blockade of CXC Chemokines/CXCR2 Axis Inhibits Pancreatic Ductal Adenocarcinoma Progression through Anti-angiogenesis |
| B03 | Yasumichi Inoue (The Japanese Foundation for Cancer Research) Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent breast cancer metastasis to bone |
| B04 | Fumiko Itoh (University of Tsukuba) Vascular endothelial cell-specific Smad2 and Smad3 signaling is required for blood vessel integrity |
| B05 | Kaoru Kahata (Uppsala University) An HMGA2-regulated gene signature provides a novel molecular mechanism underlying regulation of stemness in breast cancer |
| B06 | Yuto Kamiya (University of Tokyo) Smad7 inhibits transforming growth factor-b family type I receptors through two distinct modes of interaction |
| B07 | Mitsunobu R. Kano (University of Tokyo) Treating "intractable" tumours by nanoDDS and TGF-β inhibitor |
| B08 | Yoko Katsuno (University of Tokyo) Cancer-initiating cell population in diffuse-type gastric carcinoma cells has high ALDH1 activity |
| B09 | Daizo Koinuma (University of Tokyo) Characterization of Smad2 and Smad3 binding sites by genome-wide ChIP-chip/ChIP-sequencing analysis |
| B10 | Masako Oka (University of Colorado Denver) HGF Upregulation Contributes to Angiogenesis in Mice with Keratinocyte-Specific Smad2 Deletion |
| B11 | Seok Hee Park (Sungkyunkawn University) TGF-β1-induced MyD88 degradation is driven by Smad6-Smurf pathway, but not Smad7 |
| B12 | Hiroshi I. Suzuki (University of Tokyo) Regulation of autophagy by transforming growth factor-β (TGF-β) signaling |
| B13 | Eleftheria Vasilaki (Uppsala University) Transcriptional regulation of the small GTPase RhoB gene by TGFβ-induced signaling pathways |
| B14 | Tetsuro Watabe (University of Tokyo) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo |
